NEPHROPROTECTIVE EFFECT OF A COMBINATION OF THE PEPTIDE MIMICKING THE a-SPATIAL STRUCTURE OF THE p ERYTHROPOIETIN CHAIN AND INFLIXIMAB IN RENAL ISCHEMIA-REPERFUSION INJURY

Resume. The search for new drugs with cytoprotective and anti-ischemic activity is an urgent task of modern pharmacology. These properties are necessary the complex protection renal parenchyma during organ preservation operations (renal resection), most often carried out in conditions thermal ischemia. Only combined use highly effective skill operating surgeon can prevent development acute injury (AKI) due to pinching vessels. aim this study was investigate nephroprotective effects a combination peptide mimicking a-helix B erythropoietin (pHBSP) infliximab ischemic reperfusion damage kidneys. Methods. experiment conducted on 50 white laboratory male Wistar rats weighing 280-320 g. Animals were injected infliximab. Under anesthesia, atraumatic vascular clamps applied left pedicle 40 minutes, nephrectomy right. Functional samples tests performed 5 minutes 72 hours after reperfusion. Results. As result study, it shown that using simulating ischemic-reperfusion kidney showed significantly more pronounced than or mono mode. Conclusion.The results show promise order correct injuries.